Season 1

Cast

 * Jude Law as Pope Pius XIII (born Lenny Belardo)
 * Diane Keaton as Sister Mary
 * Silvio Orlando as Cardinal Angelo Voiello
 * Javier Cámara as Monsignor Bernardo Gutierrez (later Cardinal)
 * Scott Shepherd as Cardinal Andrew Dussolier
 * Cécile de France as Sofia
 * Ludivine Sagnier as Esther
 * Toni Bertorelli as Cardinal Caltanissetta
 * James Cromwell as Cardinal Michael Spencer